자가 탈회골의 조직반응에 관한 실험적 연구
Expermental study on healing process of autogenic demineralized bone
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이재은
이동근/엄인웅/김영조/김장연
KMID : 0360119930150030199
Abstract
Many surgeons are on the point of bone excision and reconstruction of the bone defects by autograft. xenograft, and allograft in the ireatment of begin and malignant tumors of bone. Of all type of bone grafts, we received the autograft as the
best
ideal
bone graft. Of autogenic bone graft, replantation of excised excised autogenic bone for reconstructiong the bone defects has been the ideal method until now, but early bone healing responses and tumor cell devitalization after replantation of
excised
autogenic bone have not been identified for clinical applications.
So, to evaluate bone healing response after replantation in rabbit's calvarial bone, we divided the experimental group into three groups. Grou 1 is a fresh autogenous bone group. Group 2 is a deep frozen group. Group 3 is freeze-dried
demineralized
group.
@ES Obtaine dresults were as followed:
@EN 1. Inflammatory cell infiltration appeared at I week and disappeared at 4 weeks in all experimental group, Especially, severe inflammatory cell infiltration showed in fresh autogenous bone group at 2 weeks. Group 3 is the least showing group
on
the
point of inflammatory cell infiltration.
2. Osteoblastic activity evenly increased upto 4 weeks and maintained to 6 weeks and decreased after this period, especially osteoblastic activity in group 2 is less than group 1 and group 3. We can't discriminate between osteoolastic activity
of
group
1 and that of group 3.
3. In new bone formation, group 3 was more active than any other groups at early stage, but there were little differences among three experimental groups at later stage.
4. Bone resorption around the grafted bone slightly appeared at 1 week and disappeared at 4 weeks in all experimental groups. We can find the more bone resorption in group 2 at 2 weeks than any other groups.
We could suggest, as appears from our results, that freeze-dried deminiralized bone graft is the useful bon graft in the clinical applications of excised autogenic bone.
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